Publications

ACADEMICALLY ACCLAIMED

Publications

Ionoptika’s instrument and Ion Beams are routinely used to produce leading academic publications. Browse our comprehensive collection of papers to find out more about what these systems could add to your own research.

J105/ J Series III Cluster SIMS

TitleAuthorsYear
Insights from early life in the 3.45-Ga Kitty’s Gap Chert for the search for elusive life in the UniverseWestall et al.2025
Multimodal Ion Beam Imaging to Correlate Elements and Metabolites at the Micron Scale Using Water Cluster Secondary Ion Mass Spectrometry and MeV Ion Beam AnalysisCosta and von Gerichten et al.2025
15-Lipoxygenase-dependent radiomitigation by NO●-Donors suppresses ferroptosis in intestinal Epithelium: Multiomics MS imaging and LC-MS evidenceTyurina, Tian and Dar et al.2025
Detection of a Biomolecule, Allantoin, in Skin Tissue Using Water Gas Cluster Ion Beam Time-Of-Flight Secondary Ion Mass SpectrometryAoyagi et al.2025
Enhanced Formation of Multiply Charged Protein and Peptide Ions in SIMS Using Large Water ClustersLagator et al.2025
Mapping the Molecular Landscape of Human DLBCL by GCIB-SIMSUzoni et al.2025
PCA, PC-CVA, and Random Forest of GCIB-SIMS Data for the Elucidation of Bacterial Envelope Differences in Antibiotic Resistance ResearchFransson et al.2024
ToF-SIMS imaging reveals changes in tumor cell lipids during metastatic progression of melanomaNeittaanmäki et al.2024
Lipid organization and turnover in the plasma membrane of human differentiating neural progenitor cells revealed by time-of-flight secondary ion mass spectrometry imagingBerlin et al.2024
Reactive gas cluster ion beams for enhanced drug analysis by secondary ion mass spectrometryLagator et al.2024
Ferroptosis of select skin epithelial cells initiates
and maintains chronic systemic immune-mediated
psoriatic disease		Vats et al.2024
Omega-3 and -6 Fatty Acids Alter the Membrane Lipid Composition and Vesicle Size to Regulate Exocytosis and Storage of CatecholaminesGu et al.2024
Multimodal mass spectrometry imaging identifies cell-type-specific metabolic and lipidomic variation in the mammalian liverTian et al.2024
Cell and tissue imaging by secondary ion mass spectrometryBarut & Fletcher2023
Comparing sputter rates, depth resolution, and ion yields for different Gas Cluster Ion Beams (GCIB): A practical guide to choosing the best GCIB for every applicationSano, Bellew and Blenkinsopp2023
Sensitivity enhancement using chemically reactive Gas Cluster Ion Beams in secondary ion mass spectrometry (SIMS)Lagator, Berrueta Razo, Royle and Lockyer2022
Direct Mapping of Phospholipid Ferroptotic Death Signals in Cells and Tissues by Gas Cluster Ion Beam Secondary Ion Mass Spectrometry (GCIB-SIMS)Sparvero et al.2021
Secondary Ion Mass Spectrometry Imaging Reveals Changes in the Lipid Structure of the Plasma Membranes of Hippocampal Neurons following Drugs Affecting Neuronal ActivityGonzalez et al.2021
(CO2)n+, (H2O)n+, and (H2O)n+ (CO2) gas cluster Ion Beam secondary ion mass spectrometry: analysis of lipid extracts, cells, and Alzheimer's model mouse brain tissueDimovska Nilsson et al.2021
Imaging mass spectrometry: a new way to distinguish dermal contact from administration of cocaine, using a single fingerprintCosta et al.2021
Multiomics Imaging Using High-Energy Water Gas Cluster Ion Beam Secondary Ion Mass Spectrometry [(H2O)n-GCIB-SIMS] of Frozen-Hydrated Cells and TissueTian et al.2021
Successive High-Resolution (H2O)n-GCIB and C60-SIMS Imaging Integrates Multi-Omics in Different Cell Types in Breast Cancer TissueTian et al.2021
Interplay between Cocaine, Drug Removal, and Methylphenidate Reversal on Phospholipid Alterations in Drosophila Brain Determined by Imaging Mass SpectrometryPhilipsen, Phan, Fletcher and Ewing2020
Correlated fluorescence microscopy and multi-Ion Beam secondary ion mass spectrometry imaging reveals phosphatidylethanolamine increases in the membrane of cancer cells over-expressing the molecular chaperone subunit CCTdFletcher et al.2020
Metabolomics and mass spectrometry imaging reveal channeled de novo purine synthesis in cellsPareek, Tian, Winograd and Benkovic2020
New insights into ToF-SIMS imaging in osteoporotic bone researchKern et al.2020
TOF-SIMS imaging reveals tumor heterogeneity and inflammatory response markers in the microenvironment of basal cell carcinomaDimovska Nilsson et al.2020
Interrogation of chemical changes on, and through, the bacterial envelope of Escherichia coli FabF mutant using time-of-flight secondary ion mass spectrometryDimovska Nilsson et al.2020
Localised lipid accumulation detected in infarcted mouse heart tissue using ToF-SIMSSämfors et al.2019
SIMS imaging in neuro- and cell biologyAgüi-Gonzalez, Jähne, and Phan2019
Secondary-Ion Mass Spectrometry Images Cardiolipins and Phosphatidylethanolamines at the Subcellular LevelTian et al.2019
Insights into the histology of planarian flatworm Phagocata gracilis based on location specific, intact lipid information provided by GCIB-ToF-SIMS imagingAngerer et al.2019
Enhanced Ion Yields Using High Energy Water Cluster Beams for Secondary Ion Mass Spectrometry Analysis and ImagingSheraz et al.2019
Chemical Changes On, and Through, The Bacterial Envelope in Escherichia coli Mutants Exhibiting Impaired Plasmid Transfer Identified Using Time-of-Flight Secondary Ion Mass SpectrometryDimovska Nilsson et al.2019
Exploiting the Semidestructive Nature of Gas Cluster Ion Beam Time-of-Flight Secondary Ion Mass Spectrometry Imaging for Simultaneous Localization and Confident Lipid AnnotationsAngerer et al.2019
C-O Bond Dissociation and Induced Chemical Ionization Using High Energy (CO2)n+ Gas Cluster Ion BeamTian et al.2019
The influence of polyatomic primary ion chemistry on matrix effects in secondary ion mass spectrometry analysisAlnajeebi, Vickerman and Lockyer2018
Chemical imaging of aggressive basal cell carcinoma using time-of-flight secondary ion mass spectrometryMunem et al.2018
On-Tissue Chemical Derivatization of Catecholamines Using 4-(N-Methyl)pyridinium Boronic Acid for ToF-SIMS and LDI-ToF Mass Spectrometry ImagingKaya et al.2018
MS/MS analysis and imaging of lipids across Drosophila brain using secondary ion mass spectrometryPhan, Munem, Ewing and Fletcher2017
Label-free visualization of nilotinib-functionalized gold nanoparticles within single mammalian cells by C60- SIMS imagingBloom, Tian, Schoen and Winograd2017
Gas Cluster Ion Beam Time-of-Flight Secondary Ion Mass Spectrometry High-Resolution Imaging of Cardiolipin Speciation in the Brain: Identification of Molecular Losses after Traumatic InjuryTian et al.2017
Subcellular Chemical Imaging of Antibiotics in Single Bacteria Using C60-Secondary Ion Mass SpectrometryTian et al.2017
Reduce the matrix effect in biological tissue imaging using dynamic reactive ionization and Gas Cluster Ion BeamsTian, Wucher and Winograd2016
Intact lipid imaging of mouse brain samples: MALDI, nanoparticle-laser desorption ionization, and 40 keV argon cluster secondary ion mass spectrometryMohammadi, Phan, Fletcher and Ewing2016
Lipid Heterogeneity Resulting from Fatty Acid Processing in the Human Breast Cancer Microenvironment Identified by GCIB-ToF-SIMS ImagingAngerer, Magnusson, Landberg and Fletcher2016
Matrix effects in biological SIMS using cluster Ion Beams of different chemical compositionAlnajeebi, Vickerman and Lockyer2016
Optimizing sample preparation for anatomical determination in the hippocampus of rodent brain by ToF-SIMS analysisAngerer, Mohammadi and Fletcher2016
Rapid multivariate analysis of 3D ToF-SIMS data: graphical processor units (GPUs) and low-discrepancy subsampling for large-scale principal component analysisCumpson, Fletcher, Sano and Barlow2016
Evaluation of biomolecular distributions in rat brain tissues by means of ToF-SIMS using a continuous beam of Ar clustersNakano et al.2016
Design and Manufacture of a High Resolution Orbital-Trapping Mass-Analyser for Secondary Ion Mass SpectrometryHood and Cumpson2016
Reducing the Matrix Effect in Organic Cluster SIMS Using Dynamic Reactive IonizationTian, Wucher and Winograd2016
CO2 Cluster Ion Beam, an Alternative Projectile for Secondary Ion Mass SpectrometryTian et al.2016
Gas Cluster Ion Beam for the characterization of organic materials in submarine basalts as Mars analogsSano et al.2016
Peptide Fragmentation and Surface Structural Analysis by Means of ToF-SIMS Using Large Cluster Ion SourcesYokoyama et al.2016
Comparing depth profiling of oxide scale on SOFC interconnect-materials using ToF-SIMS with 69Ga+, Bi3+/Cs+ and C60+/C602+ as primary and sputter ionsHall, Fletcher, Canovic and Malmberg2015
Significant Enhancement of Negative Secondary Ion Yields by Cluster Ion Bombardment Combined with Cesium FloodingPhilipp et al.2015
Latest applications of 3D ToF-SIMS bio-imagingFletcher2015
Lipid Structural Effects of Oral Administration of Methylphenidate in Drosophila Brain by Secondary Ion Mass Spectrometry ImagingPhan, Fletcher and Ewing2015
Multivariate analysis of extremely large ToFSIMS imaging datasets by a rapid PCA methodCumpson et al.2015
Molecular Depth Profiling with Argon Gas Cluster Ion BeamsShen, Wucher and Winograd2015
Measuring Compositions in Organic Depth Profiling: Results from a VAMAS Interlaboratory StudyShard et al.2015
Enhancing Ion Yields in Time-of-Flight-Secondary Ion Mass Spectrometry: A Comparative Study of Argon and Water Cluster Primary BeamsSheraz née Rabbani et al.2015
Improved Molecular Imaging in Rodent Brain with Time-of-Flight-Secondary Ion Mass Spectrometry Using Gas Cluster Ion Beams and Reactive Vapor ExposureAngerer, Dowlatshahi Pour, Malmberg and Fletcher2015
Mass spectrometric imaging of brain tissue by time-of-flight secondary ion mass spectrometry How do polyatomic primary beams C60+, Ar2000+, water-doped Ar2000+ and (H2O)6000+ compare?Berrueta Razoet al.2015
C60-SIMS imaging of nanoparticles within mammalian cellsBloom, Tian and Winograd2015
High energy gas cluster ions for organic and biological analysis by time-of-flight secondary ion mass spectrometryAngerer, Blenkinsopp, Fletcher2014
Comparing C60+ and (H2O)n+ clusters for mouse brain tissue analysisBerrueta Razo, Sheraz, Henderson, Lockyer and Vickerman2014
Prospect of increasing secondary ion yields in ToF-SIMS using water cluster primary Ion BeamsSheraz et al.2014
Spatiotemporal lipid profiling during early embryo development of Xenopus laevis using dynamic ToF-SIMS imagingTian et al.2014